DEEP-EP: Identification of epigenetic protein by ensemble residual convolutional neural network for drug discovery.
Methods
; 226: 49-53, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38621436
ABSTRACT
Epigenetic proteins (EP) play a role in the progression of a wide range of diseases, including autoimmune disorders, neurological disorders, and cancer. Recognizing their different functions has prompted researchers to investigate them as potential therapeutic targets and pharmacological targets. This paper proposes a novel deep learning-based model that accurately predicts EP. This study introduces a novel deep learning-based model that accurately predicts EP. Our approach entails generating two distinct datasets for training and evaluating the model. We then use three distinct strategies to transform protein sequences to numerical representations Dipeptide Deviation from Expected Mean (DDE), Dipeptide Composition (DPC), and Group Amino Acid (GAAC). Following that, we train and compare the performance of four advanced deep learning models algorithms Ensemble Residual Convolutional Neural Network (ERCNN), Generative Adversarial Network (GAN), Convolutional Neural Network (CNN), and Gated Recurrent Unit (GRU). The DDE encoding combined with the ERCNN model demonstrates the best performance on both datasets. This study demonstrates deep learning's potential for precisely predicting EP, which can considerably accelerate research and streamline drug discovery efforts. This analytical method has the potential to find new therapeutic targets and advance our understanding of EP activities in disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neural Networks, Computer
/
Drug Discovery
/
Deep Learning
Limits:
Humans
Language:
En
Journal:
Methods
/
Methods (S. Diego)
/
Methods (San Diego)
Journal subject:
BIOQUIMICA
Year:
2024
Type:
Article