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Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.
Shendy, Noha A M; Bikowitz, Melissa; Sigua, Logan H; Zhang, Yang; Mercier, Audrey; Khashana, Yousef; Nance, Stephanie; Liu, Qi; Delahunty, Ian M; Robinson, Sarah; Goel, Vanshita; Rees, Matthew G; Ronan, Melissa A; Wang, Tingjian; Kocak, Mustafa; Roth, Jennifer A; Wang, Yingzhe; Freeman, Burgess B; Orr, Brent A; Abraham, Brian J; Roussel, Martine F; Schonbrunn, Ernst; Qi, Jun; Durbin, Adam D.
Affiliation
  • Shendy NAM; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Bikowitz M; Drug Discovery Department, Moffitt Cancer Center, Tampa, FL, USA.
  • Sigua LH; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Zhang Y; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Mercier A; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Khashana Y; Tumor Cell Biology Department, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Nance S; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Liu Q; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Delahunty IM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Robinson S; Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Goel V; Tumor Cell Biology Department, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Rees MG; Tumor Cell Biology Department, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Ronan MA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Wang T; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kocak M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Roth JA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Wang Y; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Freeman BB; Preclinical Pharmacokinetics Shared Resource, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Orr BA; Preclinical Pharmacokinetics Shared Resource, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Abraham BJ; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Roussel MF; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Schonbrunn E; Tumor Cell Biology Department, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Qi J; Drug Discovery Department, Moffitt Cancer Center, Tampa, FL, USA. Ernst.Schonbrunn@moffitt.org.
  • Durbin AD; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Ernst.Schonbrunn@moffitt.org.
Nat Commun ; 15(1): 3483, 2024 Apr 25.
Article in En | MEDLINE | ID: mdl-38664416
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: E1A-Associated p300 Protein / Gene Regulatory Networks / Medulloblastoma Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: E1A-Associated p300 Protein / Gene Regulatory Networks / Medulloblastoma Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Type: Article Affiliation country: United States