Four New Polyprenylated Acylphloroglucinols from Hypericum perforatum L.
Molecules
; 29(8)2024 Apr 12.
Article
in En
| MEDLINE
| ID: mdl-38675576
ABSTRACT
Hyperforatums A-D (1-4), four new polyprenylated acylphloroglucinols, together with 13 known compounds were isolated and identified from the aerial parts of Hypericum perforatum L. (St. John's wort). Their structures were confirmed with a comprehensive analysis comprising spectroscopic methods, including 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Hyperforatum A featured an unusual chromene-1,4-dione bicyclic system, and hyperforatums B and C were two rare monocyclic PPAPs with five-membered furanone cores. Compound 1 exhibited a moderate inhibition effect on NO production in BV-2 microglial cells stimulated by LPS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phloroglucinol
/
Hypericum
Limits:
Animals
Language:
En
Journal:
Molecules
/
Molecules (Basel)
Journal subject:
BIOLOGIA
Year:
2024
Type:
Article
Affiliation country:
China