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HPLC-Based Automated Synthesis and Purification of Carbohydrates.
Kashiwagi, Gustavo A; Petrosilli, Laura; Escopy, Samira; Lay, Luigi; Stine, Keith J; De Meo, Cristina; Demchenko, Alexei V.
Affiliation
  • Kashiwagi GA; Department of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.
  • Petrosilli L; Department of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.
  • Escopy S; Department of Chemistry, University of Milan, Via Golgi 19, Milan, 20133, Italy.
  • Lay L; Department of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.
  • Stine KJ; Department of Chemistry and Biochemistry, University of Missouri St. Louis, One University Boulevard, St. Louis, Missouri, 63121, USA.
  • De Meo C; Department of Chemistry, University of Milan, Via Golgi 19, Milan, 20133, Italy.
  • Demchenko AV; Department of Chemistry and Biochemistry, University of Missouri St. Louis, One University Boulevard, St. Louis, Missouri, 63121, USA.
Chemistry ; 30(43): e202401214, 2024 Aug 01.
Article in En | MEDLINE | ID: mdl-38684455
ABSTRACT
Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligosaccharides / Carbohydrates Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2024 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligosaccharides / Carbohydrates Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2024 Type: Article Affiliation country: United States