Y chromosome haplogroups are associated with birth size in Japanese men.
J Med Invest
; 71(1.2): 129-133, 2024.
Article
in En
| MEDLINE
| ID: mdl-38735708
ABSTRACT
The Y chromosome is classified into haplogroups (A-T) based on a combination of several DNA polymorphisms. Japanese men are mainly classified into haplogroups C, D, and O, which have been further subdivided. The distribution of Y-chromosome haplogroups varies by ethnicity. The phylogenetic age, origin, and migration also differ. I hypothesized that Y chromosome haplogroups may be associated with height and/or weight at birth. An association analysis of height and weight at birth with Y chromosome haplogroups was performed in 288 Japanese men. Men belonging to haplogroup O1b2 were significantly associated with short stature at birth (beta = ï¼1.88, standard error (SE) = 0.55, P = 0.00076), and those belonging to D1a2a-12f2b were significantly associated with increased birth weight (beta = 174, SE = 64, P = 0.0069). Y chromosome haplogroups are associated with physical birth characteristics in modern Japanese men. J. Med. Invest. 71 129-133, February, 2024.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Birth Weight
/
Haplotypes
/
Chromosomes, Human, Y
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
J Med Invest
Journal subject:
MEDICINA
Year:
2024
Type:
Article
Affiliation country:
Japan