Exploring the connections between ER-based lipid metabolism and plasma membrane nanodomain signaling.
New Phytol
; 243(1): 48-57, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38757654
ABSTRACT
Recent advancements in our understanding of cell membrane dynamics have shed light on the importance of plasma membrane (PM) nanodomains in plant cell signaling. Nevertheless, many aspects of membrane nanodomains, including their regulatory mechanisms and biological functions, remain enigmatic. To address this knowledge gap, our review article proposes a novel perspective wherein signaling pathways target endoplasmic reticulum (ER)-based lipid metabolism to exert control over the formation and function of membrane nanodomains. Subsequently, these nanodomains reciprocate by influencing the localization and activity of signaling molecules at the PM. We place a specific emphasis on ER-based enzymatic reactions, given the ER's central role in membrane lipid biosynthesis and its capacity to directly impact PM lipid composition, particularly with regard to saturation levels - an essential determinant of nanodomain properties. The interplay among cell signaling, glycerolipid metabolism, and PM nanodomain may create feedforward/feedback loops that fine-tune cellular responses to developmental and environmental cues.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Cell Membrane
/
Endoplasmic Reticulum
/
Lipid Metabolism
Language:
En
Journal:
New Phytol
Journal subject:
BOTANICA
Year:
2024
Type:
Article
Affiliation country:
Canada