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Hepatitis B virus DNA and RNA persist in liver after serologic recovery in persons with hepatitis C virus.
Grudda, Tanner; Thomas, David L; Kirk, Gregory D; Mehta, Shruti H; Astemborski, Jacquie; Lauer, Georg M; Balagopal, Ashwin; Thio, Chloe L.
Affiliation
  • Grudda T; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Thomas DL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Kirk GD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Mehta SH; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Astemborski J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Lauer GM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Balagopal A; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Thio CL; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
J Infect Dis ; 2024 May 23.
Article in En | MEDLINE | ID: mdl-38779916
ABSTRACT
After recovery from a hepatitis B virus (HBV) infection, reactivation can occur with immunosuppression; thus, it is assumed that replication competent HBV persists in the liver. We sought to detect persistent HBV from 13 people with spontaneous recovery. We quantified HBV DNA and RNA in core liver biopsies (median 1.72x106 cells) from people who inject drugs (PWID). Among 13 biopsies, 8 (61%) had evidence of HBV DNA or RNA and 5 (38%) had both HBV DNA and RNA. mRNAs derived from cccDNA and integrated HBV DNA. Here, we show prevalent HBV DNA and RNA despite clinical recovery in PWID.
We used a sensitive method to determine the amount of hepatitis B virus DNA or RNA in the livers of 13 individuals who recovered from hepatitis B virus infection. We found viral DNA or RNA in the liver in 61% of individuals despite no detectable virus in blood. Our findings support that eliminating all hepatitis B from the liver is a difficult treatment goal.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Infect Dis / J. infect. dis / Journal of infectious diseases Year: 2024 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Infect Dis / J. infect. dis / Journal of infectious diseases Year: 2024 Type: Article Affiliation country: United States