Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database.

Adachi, Koichiro; Ohyama, Katsuhiro; Tanaka, Yoichi; Murayama, Norie; Shimizu, Makiko; Saito, Yoshiro; Yamazaki, Hiroshi

Adachi, Koichiro; Ohyama, Katsuhiro; Tanaka, Yoichi; Murayama, Norie; Shimizu, Makiko; Saito, Yoshiro; Yamazaki, Hiroshi.

Affiliation

Adachi K; Showa Pharmaceutical University.
Ohyama K; School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
Tanaka Y; National Institute of Health Sciences.
Murayama N; Showa Pharmaceutical University.
Shimizu M; Showa Pharmaceutical University.
Saito Y; National Institute of Health Sciences.
Yamazaki H; Showa Pharmaceutical University.

Biol Pharm Bull ; 47(5): 1028-1032, 2024.

Article in En | MEDLINE | ID: mdl-38797695

Subject(s)

Cytochrome P-450 CYP2C19; Liver; Omeprazole; Proton Pump Inhibitors; Humans; Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury/etiology; Chemical and Drug Induced Liver Injury/blood; Cytochrome P-450 CYP2C19/genetics; Cytochrome P-450 CYP2C19/metabolism; Databases, Factual; East Asian People; Japan; Liver/metabolism; Liver/drug effects; Models, Biological; Omeprazole/pharmacokinetics; Omeprazole/adverse effects; Omeprazole/blood; Omeprazole/administration & dosage; Proton Pump Inhibitors/adverse effects; Proton Pump Inhibitors/administration & dosage; Proton Pump Inhibitors/pharmacokinetics; Proton Pump Inhibitors/blood

Key words

CYP2C19; autoinduction; physiologically based pharmacokinetic modeling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Omeprazole / Proton Pump Inhibitors / Cytochrome P-450 CYP2C19 / Liver Limits: Humans Country/Region as subject: Asia Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2024 Type: Article

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