Afatinib-induced toxic epidermal necrolysis: A case report with a literature review.

Belancic, Andrej; Hlaca, Nika; Peternel, Sandra; Golcic, Marin; Prpic-Massari, Larisa; Vlahovic-Palcevski, Vera

Belancic, Andrej; Hlaca, Nika; Peternel, Sandra; Golcic, Marin; Prpic-Massari, Larisa; Vlahovic-Palcevski, Vera.

Affiliation

Belancic A; Department of Clinical Pharmacology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Hlaca N; Department of Basic and Clinical Pharmacology With Toxicology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Peternel S; Department of Dermatovenerology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Golcic M; Department of Dermatovenerology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Prpic-Massari L; Department of Dermatovenerology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Vlahovic-Palcevski V; Department of Dermatovenerology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

Br J Clin Pharmacol ; 90(8): 2030-2033, 2024 Aug.

Article in En | MEDLINE | ID: mdl-38803188

ABSTRACT

ABSTRACT

We present a 70-year-old female patient diagnosed with epidermal growth factor receptor-mutated metastatic non-small cell lung cancer (T4N2M1a), who developed afatinib-induced toxic epidermal necrolysis (TEN). We have also performed a PubMed/Medline literature review to detect other possible cases of TEN/Stevens-Johnson syndrome associated with afatinib treatment and found only 5 other cases reported. To our best knowledge, this is the first case of afatinib-induced TEN successfully treated with cyclosporine.

Subject(s)

Afatinib; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Stevens-Johnson Syndrome; Humans; Afatinib/adverse effects; Afatinib/therapeutic use; Female; Aged; Stevens-Johnson Syndrome/etiology; Stevens-Johnson Syndrome/drug therapy; Lung Neoplasms/drug therapy; Carcinoma, Non-Small-Cell Lung/drug therapy; Quinazolines/adverse effects; Quinazolines/therapeutic use; Antineoplastic Agents/adverse effects; Cyclosporine/adverse effects; Cyclosporine/therapeutic use; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/genetics

Key words

afatinib; pharmacovigilance; serious adverse drug reaction; toxic epidermal necrolysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stevens-Johnson Syndrome / Carcinoma, Non-Small-Cell Lung / Afatinib / Lung Neoplasms Limits: Aged / Female / Humans Language: En Journal: Br J Clin Pharmacol / Br. j. clin. pharmacol / British journal of clinical pharmacology Year: 2024 Type: Article Affiliation country: Croatia

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