Immunogenicity evaluation of primary polio vaccination schedule with inactivated poliovirus vaccines and bivalent oral poliovirus vaccine.
BMC Infect Dis
; 24(1): 535, 2024 May 28.
Article
in En
| MEDLINE
| ID: mdl-38807038
ABSTRACT
BACKGROUND:
To assess the immunogenicity of the current primary polio vaccination schedule in China and compare it with alternative schedules using Sabin or Salk-strain IPV (sIPV, wIPV).METHODS:
A cross-sectional investigation was conducted at four sites in Chongqing, China, healthy infants aged 60-89 days were conveniently recruited and divided into four groups according to their received primary polio vaccination schedules (2sIPV + bOPV, 2wIPV + bOPV, 3sIPV, and 3wIPV). The sero-protection and neutralizing antibody titers against poliovirus serotypes (type 1, 2, and 3) were compared after the last dose.RESULTS:
There were 408 infants completed the protocol. The observed seropositivity was more than 96% against poliovirus types 1, 2, and 3 in all groups. IPV-only groups induced higher antibody titers(GMT) against poliovirus type 2 (Median192, QR 96-384, P<0.05) than the "2IPV + bOPV" group. While the "2IPV + bOPV" group induced significantly higher antibody titers against poliovirus type 1 (Median2048, QR 768-2048, P<0.05)and type 3 (Median2048, QR 512-2048, P<0.05) than the IPV-only group.CONCLUSIONS:
Our findings have proved that the two doses of IPV with one dose of bOPV is currently the best polio routine immunization schedule in China.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Poliomyelitis
/
Poliovirus Vaccine, Inactivated
/
Poliovirus Vaccine, Oral
/
Immunization Schedule
/
Poliovirus
/
Antibodies, Neutralizing
/
Antibodies, Viral
Limits:
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
BMC Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2024
Type:
Article
Affiliation country:
China