Effects of cold acclimation on serum biochemical parameters and metabolite profiles in Schizothorax prenanti.
BMC Genomics
; 25(1): 547, 2024 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-38824590
ABSTRACT
BACKGROUND:
Environmental temperature is critical in regulating biological functions in fish. S. prenanti is a kind of cold-water fish, but of which we have little knowledge about the metabolic adaptation and physiological responses to long-term cold acclimation.RESULTS:
In this study, we determined the physiological responses of S. prenanti serum after 30 days of exposure to 6â. Compared with the control group, the levels of TC, TG, and LDL-C in the serum were significantly (P < 0.05) increased, and the level of glucose was significantly (P < 0.05) decreased under cold acclimation. Cold acclimation had no effect on the gene expression of pro-inflammatory factors and anti-inflammatory factors of S. prenanti. Metabolomics analysis by LC-MS showed that a total of 60 differential expressed metabolites were identified after cold acclimation, which involved in biosynthesis of amino acids, biosynthesis of unsaturated fatty acids, steroid degradation, purine metabolism, and citrate cycle pathways.CONCLUSION:
The results indicate that cold acclimation can alter serum metabolites and metabolic pathways to alter energy metabolism and provide insights for the physiological regulation of cold-water fish in response to cold acclimation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyprinidae
/
Cold Temperature
/
Metabolome
/
Metabolomics
/
Acclimatization
Limits:
Animals
Language:
En
Journal:
BMC Genomics
Journal subject:
GENETICA
Year:
2024
Type:
Article
Affiliation country:
China