Symptomatic Clusters Related to Amyloid Positivity in Cognitively Unimpaired Individuals.
J Alzheimers Dis
; 100(1): 193-205, 2024.
Article
in En
| MEDLINE
| ID: mdl-38848176
ABSTRACT
Background:
The NIA-AA Research Framework on Alzheimer's disease (AD) proposes a transitional stage (stage 2) characterized by subtle cognitive decline, subjective cognitive decline (SCD) and mild neurobehavioral symptoms (NPS).Objective:
To identify participant clusters based on stage 2 features and assess their association with amyloid positivity in cognitively unimpaired individuals.Methods:
We included baseline data of Nâ=â338 cognitively unimpaired participants from the DELCODE cohort with data on cerebrospinal fluid biomarkers for AD. Classification into the AD continuum (i.e., amyloid positivity, A+) was based on Aß42/40 status. Neuropsychological test data were used to assess subtle objective cognitive dysfunction (OBJ), the subjective cognitive decline interview (SCD-I) was used to detect SCD, and the Neuropsychiatric Inventory Questionnaire (NPI-Q) was used to assess NPS. A two-step cluster analysis was carried out and differences in AD biomarkers between clusters were analyzed.Results:
We identified three distinct participant clusters based on presented symptoms. The highest rate of A+âparticipants (47.6%) was found in a cluster characterized by both OBJ and SCD. A cluster of participants that presented with SCD and NPS (A+26.6%) and a cluster of participants with overall few symptoms (A+19.7%) showed amyloid positivity in a range that was not higher than the expected A+ rate for the age group. Across the full sample, participants with a combination of SCD and OBJ in the memory domain showed a lower Aß42/ptau181 ratio compared to those with neither SCD nor OBJ.Conclusions:
The cluster characterized by participants with OBJ and concomitant SCD was enriched for amyloid pathology.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Biomarkers
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Amyloid beta-Peptides
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Alzheimer Disease
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Cognitive Dysfunction
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Neuropsychological Tests
Limits:
Aged
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Aged80
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2024
Type:
Article
Affiliation country:
Germany