Mitochondrial DNA release via the mitochondrial permeability transition pore activates the cGAS-STING pathway, exacerbating inflammation in acute Kawasaki disease.

Wei, Ke; Chen, Tao; Fang, Hao; Shen, Xianjuan; Tang, Zhiyuan; Zhao, Jianmei

Wei, Ke; Chen, Tao; Fang, Hao; Shen, Xianjuan; Tang, Zhiyuan; Zhao, Jianmei.

Affiliation

Wei K; Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
Chen T; Research Institute of Comparative Medicine, Nantong University, Nantong, 226001, Jiangsu Province, China.
Fang H; Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
Shen X; Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
Tang Z; Department of Clinical Laboratory, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
Zhao J; Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China. tina2951@sina.com.

Cell Commun Signal ; 22(1): 328, 2024 Jun 13.

Article in En | MEDLINE | ID: mdl-38872145

Subject(s)

DNA, Mitochondrial; Inflammation; Membrane Proteins; Mitochondrial Permeability Transition Pore; Mucocutaneous Lymph Node Syndrome; Nucleotidyltransferases; Signal Transduction; Mucocutaneous Lymph Node Syndrome/metabolism; Mucocutaneous Lymph Node Syndrome/pathology; Mucocutaneous Lymph Node Syndrome/genetics; DNA, Mitochondrial/genetics; DNA, Mitochondrial/metabolism; Nucleotidyltransferases/metabolism; Nucleotidyltransferases/genetics; Humans; Membrane Proteins/metabolism; Membrane Proteins/genetics; Inflammation/pathology; Inflammation/metabolism; Inflammation/genetics; Animals; Mitochondrial Permeability Transition Pore/metabolism; Male; Mice; Human Umbilical Vein Endothelial Cells/metabolism; Female; Acute Disease; Mice, Inbred C57BL; Child, Preschool

Key words

Kawasaki disease; cGAS-STING pathway; mPTP; mtDNA

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Mitochondrial / Signal Transduction / Mitochondrial Permeability Transition Pore / Inflammation / Membrane Proteins / Mucocutaneous Lymph Node Syndrome / Nucleotidyltransferases Limits: Animals / Child, preschool / Female / Humans / Male Language: En Journal: Cell Commun Signal Year: 2024 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google