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Harnessing nanomedicine for modulating microglial states in the central nervous system disorders: Challenges and opportunities.
Li, Haisong; Guan, Meng; Zhang, Ning-Ning; Wang, Yizhuo; Liang, Tingting; Wu, Haitao; Wang, Chang; Sun, Tianmeng; Liu, Shuhan.
Affiliation
  • Li H; Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China; Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, China.
  • Guan M; Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Anim
  • Zhang NN; State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Jilin, China.
  • Wang Y; Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China.
  • Liang T; Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China.
  • Wu H; Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China.
  • Wang C; Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China. Electronic address: wangchang@jlu.edu.cn.
  • Sun T; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China; International Center of
  • Liu S; Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Anim
Biomed Pharmacother ; 177: 117011, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38917758
ABSTRACT
Microglia are essential for maintaining homeostasis and responding to pathological events in the central nervous system (CNS). Their dynamic and multidimensional states in different environments are pivotal factors in various CNS disorders. However, therapeutic modulation of microglial states is challenging due to the intricate balance these cells maintain in the CNS environment and the blood-brain barrier's restriction of drug delivery. Nanomedicine presents a promising avenue for addressing these challenges, offering a method for the targeted and efficient modulation of microglial states. This review covers the challenges faced in microglial therapeutic modulation and potential use of nanoparticle-based drug delivery systems. We provide an in-depth examination of nanoparticle applications for modulating microglial states in a range of CNS disorders, encompassing neurodegenerative and autoimmune diseases, infections, traumatic injuries, stroke, tumors, chronic pain, and psychiatric conditions. This review highlights the recent advancements and future prospects in nanomedicine for microglial modulation, paving the way for future research and clinical applications of therapeutic interventions in CNS disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Central Nervous System Diseases / Microglia / Nanomedicine Limits: Animals / Humans Language: En Journal: Biomed Pharmacother Year: 2024 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Central Nervous System Diseases / Microglia / Nanomedicine Limits: Animals / Humans Language: En Journal: Biomed Pharmacother Year: 2024 Type: Article