A role for synapsin tetramerization in synaptic vesicle clustering.
J Physiol
; 2024 Jul 09.
Article
in En
| MEDLINE
| ID: mdl-38979871
ABSTRACT
Although synapsins have long been proposed to be key regulators of synaptic vesicle (SV) clustering, their mechanism of action has remained mysterious and somewhat controversial. Here, we review synapsins and their associations with each other and with SVs. We highlight the recent hypothesis that synapsin tetramerization is a mechanism for SV clustering. This hypothesis, which aligns with numerous experimental results, suggests that the larger size of synapsin tetramers, in comparison to dimers, allows tetramers to form optimal bridges between SVs that overcome the repulsive force associated with the negatively charged membrane of SVs and allow synapsins to form a reserve pool of SVs within presynaptic terminals.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Physiol
/
J. physiol
/
Journal of physiology
Year:
2024
Type:
Article
Affiliation country:
Singapore