A gain of function mutation in PITX2c gene linked to atrial fibrillation alters mitochondrial function and membrane excitability.

Benzoni, Patrizia; Da Dalt, Lorenzo; Cospito, Alessandro; Popolizio, Vera; Giannetti, Federica; Ruberti, Cristina; Baruscotti, Mirko; Bucchi, Annalisa; Norata, Giuseppe Danilo; Barbuti, Andrea

Benzoni, Patrizia; Da Dalt, Lorenzo; Cospito, Alessandro; Popolizio, Vera; Giannetti, Federica; Ruberti, Cristina; Baruscotti, Mirko; Bucchi, Annalisa; Norata, Giuseppe Danilo; Barbuti, Andrea.

Affiliation

Benzoni P; TheCell Physiology MiLab, Dept. Biosciences, Università degli Studi di Milano, 20133 Milano, Italy.
Da Dalt L; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milano, Italy.
Cospito A; TheCell Physiology MiLab, Dept. Biosciences, Università degli Studi di Milano, 20133 Milano, Italy.
Popolizio V; TheCell Physiology MiLab, Dept. Biosciences, Università degli Studi di Milano, 20133 Milano, Italy.
Giannetti F; TheCell Physiology MiLab, Dept. Biosciences, Università degli Studi di Milano, 20133 Milano, Italy; Istituto auxologico, 20095 Cusano Milanino (MI), Italy.
Ruberti C; TheCell Physiology MiLab, Dept. Biosciences, Università degli Studi di Milano, 20133 Milano, Italy.
Baruscotti M; TheCell Physiology MiLab, Dept. Biosciences, Università degli Studi di Milano, 20133 Milano, Italy.
Bucchi A; TheCell Physiology MiLab, Dept. Biosciences, Università degli Studi di Milano, 20133 Milano, Italy.
Norata GD; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milano, Italy.
Barbuti A; TheCell Physiology MiLab, Dept. Biosciences, Università degli Studi di Milano, 20133 Milano, Italy.

Vascul Pharmacol ; 155: 107298, 2024 Jun.

Article in En | MEDLINE | ID: mdl-38985600

Subject(s)

Atrial Fibrillation; Gain of Function Mutation; Homeobox Protein PITX2; Homeodomain Proteins; Transcription Factors; Atrial Fibrillation/genetics; Atrial Fibrillation/physiopathology; Atrial Fibrillation/diagnosis; Humans; Transcription Factors/genetics; Transcription Factors/metabolism; Homeodomain Proteins/genetics; Mitochondria, Heart/genetics; Mitochondria, Heart/metabolism; Mitochondria, Heart/pathology; Animals; Membrane Potential, Mitochondrial/genetics; Genetic Predisposition to Disease; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Phenotype

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atrial Fibrillation / Transcription Factors / Homeodomain Proteins / Gain of Function Mutation / Homeobox Protein PITX2 Limits: Animals / Humans Language: En Journal: Vascul Pharmacol Journal subject: ANGIOLOGIA / FARMACOLOGIA Year: 2024 Type: Article Affiliation country: Italy

Fulltext

XML

PubMed Links

Search on Google