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Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model.
Leuzy, Antoine; Raket, Lars Lau; Villemagne, Victor L; Klein, Gregory; Tonietto, Matteo; Olafson, Emily; Baker, Suzanne; Saad, Ziad S; Bullich, Santiago; Lopresti, Brian; Bohorquez, Sandra Sanabria; Boada, Mercè; Betthauser, Tobey J; Charil, Arnaud; Collins, Emily C; Collins, Jessica A; Cullen, Nicholas; Gunn, Roger N; Higuchi, Makoto; Hostetler, Eric; Hutchison, R Matthew; Iaccarino, Leonardo; Insel, Philip S; Irizarry, Michael C; Jack, Clifford R; Jagust, William J; Johnson, Keith A; Johnson, Sterling C; Karten, Yashmin; Marquié, Marta; Mathotaarachchi, Sulantha; Mintun, Mark A; Ossenkoppele, Rik; Pappas, Ioannis; Petersen, Ronald C; Rabinovici, Gil D; Rosa-Neto, Pedro; Schwarz, Christopher G; Smith, Ruben; Stephens, Andrew W; Whittington, Alex; Carrillo, Maria C; Pontecorvo, Michael J; Haeberlein, Samantha Budd; Dunn, Billy; Kolb, Hartmuth C; Sivakumaran, Sudhir; Rowe, Christopher C; Hansson, Oskar; Doré, Vincent.
Affiliation
  • Leuzy A; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.
  • Raket LL; Critical Path for Alzheimer's Disease (CPAD) Consortium, Critical Path Institute, Tucson, Arizona, USA.
  • Villemagne VL; Enigma Biomedical Group, Knoxville, Tennessee, USA.
  • Klein G; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.
  • Tonietto M; Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Olafson E; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Baker S; Florey Department of Neuroscience, University of Melbourne, Parkville, Victoria, Australia.
  • Saad ZS; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.
  • Bullich S; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Lopresti B; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Bohorquez SS; Clinical Imaging Group, Genentech, Inc., South San Francisco, California, USA.
  • Boada M; Lawrence Berkeley National Laboratory, Berkeley, California, USA.
  • Betthauser TJ; Janssen Research & Development, Merryfield Row San Diego, California, USA.
  • Charil A; Life Molecular Imaging GmbH, Berlin, Germany.
  • Collins EC; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Collins JA; Clinical Imaging Group, Genentech, Inc., South San Francisco, California, USA.
  • Cullen N; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
  • Gunn RN; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Av. de Monforte de Lemos, Madrid, Spain.
  • Higuchi M; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Hostetler E; Department of Medicine Division of Geriatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Hutchison RM; Department of Medical Physics, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Iaccarino L; Eisai, Inc., Nutley, New Jersey, USA.
  • Insel PS; Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Irizarry MC; Biogen, Cambridge, Massachusetts, USA.
  • Jack CR; Critical Path for Alzheimer's Disease (CPAD) Consortium, Critical Path Institute, Tucson, Arizona, USA.
  • Jagust WJ; Invicro, Hammersmith Hospital, London, UK.
  • Johnson KA; Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
  • Johnson SC; Department of Functional Brain Imaging, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Inage-ku, Chiba-shi, Chiba, Japan.
  • Karten Y; Merck & Co., Inc, West Point, Pennsylvania, USA.
  • Marquié M; Biogen, Cambridge, Massachusetts, USA.
  • Mathotaarachchi S; Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Mintun MA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.
  • Ossenkoppele R; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Pappas I; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Petersen RC; University of California Berkeley, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
  • Rabinovici GD; Harvard Medical School, Department of Radiology, Boston, Minnesota, USA.
  • Rosa-Neto P; Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, Minnesota, USA.
  • Schwarz CG; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Smith R; Department of Medicine Division of Geriatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Stephens AW; Department of Medical Physics, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Whittington A; Critical Path for Alzheimer's Disease (CPAD) Consortium, Critical Path Institute, Tucson, Arizona, USA.
  • Carrillo MC; Department of Medicine Division of Geriatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Pontecorvo MJ; Department of Medical Physics, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Haeberlein SB; Enigma Biomedical Group, Knoxville, Tennessee, USA.
  • Dunn B; Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Kolb HC; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.
  • Sivakumaran S; Amsterdam University Medical Center, Neuroscience Campus Amsterdam, Alzheimercenter, HZ Amsterdam, the Netherlands.
  • Rowe CC; Department of Psychology, Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA.
  • Hansson O; Department of Neurology, VA Northern California Health Care System, Martinez, California, USA.
  • Doré V; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement ; 2024 Jul 23.
Article in En | MEDLINE | ID: mdl-39041435
ABSTRACT

INTRODUCTION:

Tau-positron emission tomography (PET) outcome data of patients with Alzheimer's disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instrumentation, and methods of analysis.

METHODS:

Using head-to-head data from five cohorts with tau PET radiotracers designed to target tau deposition in AD, we tested a joint propagation model (JPM) to harmonize quantification (units termed "CenTauR" [CTR]). JPM is a statistical model that simultaneously models the relationships between head-to-head and anchor point data. JPM was compared to a linear regression approach analogous to the one used in the amyloid PET Centiloid scale.

RESULTS:

A strong linear relationship was observed between CTR values across brain regions. Using the JPM approach, CTR estimates were similar to, but more accurate than, those derived using the linear regression approach.

DISCUSSION:

Preliminary findings using the JPM support the development and adoption of a universal scale for tau-PET quantification. HIGHLIGHTS Tested a novel joint propagation model (JPM) to harmonize quantification of tau PET. Units of common scale are termed "CenTauRs". Tested a Centiloid-like linear regression approach. Using five cohorts with head-to-head tau PET, JPM outperformed linearregressionbased approach. Strong linear relationship was observed between CenTauRs values across brain regions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Alzheimers Dement Year: 2024 Type: Article Affiliation country: Sweden
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Alzheimers Dement Year: 2024 Type: Article Affiliation country: Sweden