Expression of CD45 in non-hematopoietic cells: implications in regenerative medicine and disease management.
Regen Med
; 19(7-8): 407-419, 2024.
Article
in En
| MEDLINE
| ID: mdl-39058408
ABSTRACT
CD45 plays a crucial role in the regulation of hematopoiesis. However, a comprehensive understanding of its role in non-hematopoietic cells is lacking. Several tissue precursors express CD45, indicating its crucial role in tissue regeneration. These precursors would fall prey to the recent therapies involving CD45 as a target. CD45+ double-positive tumor cells contribute to cancer progression, but whether CD45 is involved in the process needs to be investigated. Recently, we showed that aging induces CD45 expression in mesenchymal stromal cells and affects their differentiation potential. In this review, we, for the first time, unravel the important implications of the expression of CD45 in non-hematopoietic cells and provide novel insights into its potential therapeutic target in regenerative medicine and disease management.
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Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukocyte Common Antigens
/
Regenerative Medicine
Limits:
Animals
/
Humans
Language:
En
Journal:
Regen Med
Year:
2024
Type:
Article
Affiliation country:
India