Deep learning based method for predicting DNA N6-methyladenosine sites.
Methods
; 230: 91-98, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39097179
ABSTRACT
DNA N6 methyladenine (6mA) plays an important role in many biological processes, and accurately identifying its sites helps one to understand its biological effects more comprehensively. Previous traditional experimental methods are very labor-intensive and traditional machine learning methods also seem to be somewhat insufficient as the database of 6mA methylation groups becomes progressively larger, so we propose a deep learning-based method called multi-scale convolutional model based on global response normalization (CG6mA) to solve the prediction problem of 6mA site. This method is tested with other methods on three different kinds of benchmark datasets, and the results show that our model can get more excellent prediction results.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenosine
/
DNA Methylation
/
Deep Learning
Limits:
Humans
Language:
En
Journal:
Methods
/
Methods (S. Diego)
/
Methods (San Diego)
Journal subject:
BIOQUIMICA
Year:
2024
Type:
Article
Affiliation country:
China