Chemical Characterization of Pruning Wood Extracts from Six Japanese Plum (Prunus salicina Lindl.) Cultivars and Their Antitumor Activity.
Molecules
; 29(16)2024 Aug 16.
Article
in En
| MEDLINE
| ID: mdl-39202966
ABSTRACT
The Japanese plum tree (Prunus salicina Lindl.) is mainly cultivated in temperate areas of China and some European countries. Certain amounts of wood (from pruning works) are generated every year from this crop of worldwide commercial significance. The main objective of this work was to value this agricultural woody residue, for which the chemical composition of pruning wood extracts from six Japanese plum cultivars was investigated, and the antiproliferative activity of extracts and pure phenolics present in those extracts was measured. For the chemical characterization, total phenolic content and DPPH radical-scavenging assays and HPLCâDAD/ESIâMS analyses were performed, with the procyanidin (-)-ent-epicatechin-(2αâOâ7,4αâ8)-epicatechin (5) and the propelargonidin (+)-epiafzelechin-(2ßâOâ7,4ßâ8)-epicatechin (7) being the major components of the wood extracts. Some quantitative differences were found among plum cultivars, and the content of proanthocyanidins ranged from 1.50 (cv. 'Fortune') to 4.44 (cv. 'Showtime') mg/g of dry wood. Regarding the antitumoral activity, eight wood extracts and four phenolic compounds were evaluated in MCF-7 cells after 48 h of induction, showing the wood extract from cv. 'Songold' and (â)-annphenone (3), the best antiproliferative activity (IC50 424 µg/mL and 405 µg/mL, respectively).
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wood
/
Plant Extracts
Limits:
Humans
Language:
En
Journal:
Molecules
/
Molecules (Basel)
Journal subject:
BIOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Spain