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Impact of HLA allele-KIR partners on sexually transmitted HIV-1 infection.
Serrano-Rísquez, Carmen; Omar, Mohamed; Rallón, Norma; Benito, José Miguel; Gómez-Vidal, Amparo; Márquez, Francisco José; Alján, Martina; Rivero-Juárez, Antonio; Pérez-Valero, Ignacio; Rivero, Antonio; Sinangil, Faruk; Saulle, Irma; Biasin, Mara; Clerici, Mario; Forthal, Donald; Saéz, Maria Eugenia; Caruz, Antonio.
Affiliation
  • Serrano-Rísquez C; Unidad de Inmunogenética, Genética, Departamento de Biología Experimental, Universidad de Jaén, 23071 Jaén, Spain.
  • Omar M; Servicio de Enfermedades Infecciosas y Microbiología Clínica, Complejo Hospitalario de Jaén, 23007 Jaén, Spain.
  • Rallón N; HIV and Viral Hepatitis Research Laboratory, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.
  • Benito JM; Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain.
  • Gómez-Vidal A; Servicio de Enfermedades Infecciosas y Microbiología Clínica, Complejo Hospitalario de Jaén, 23007 Jaén, Spain.
  • Márquez FJ; Unidad de Inmunogenética, Genética, Departamento de Biología Experimental, Universidad de Jaén, 23071 Jaén, Spain.
  • Alján M; Unidad de Inmunogenética, Genética, Departamento de Biología Experimental, Universidad de Jaén, 23071 Jaén, Spain.
  • Rivero-Juárez A; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía, 14004 Córdoba, Spain.
  • Pérez-Valero I; CIBERINFEC, ISCIII - CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Rivero A; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía, 14004 Córdoba, Spain.
  • Sinangil F; CIBERINFEC, ISCIII - CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Saulle I; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía, 14004 Córdoba, Spain.
  • Biasin M; CIBERINFEC, ISCIII - CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Clerici M; Global Solutions for Infectious Diseases, Lafayette, 94549 CA, USA.
  • Forthal D; Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milan, Italy.
  • Saéz ME; Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milan, Italy.
  • Caruz A; Dipartimento di Fisiopatologia Medico-Chirurgica e Trapianti. Università degli Studi di Milano, Milan, Italy.
J Infect Dis ; 2024 Aug 29.
Article in En | MEDLINE | ID: mdl-39208444
ABSTRACT
HLA-I/KIR genotypes influence HIV-1 disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route-parenteral vs. sexual-may influence this association. We conducted a GWAS in a population of people living with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Infect Dis / J. infect. dis / Journal of infectious diseases Year: 2024 Type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Infect Dis / J. infect. dis / Journal of infectious diseases Year: 2024 Type: Article Affiliation country: Spain