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A second-generation recombinant BCG strain combines protection against murine tuberculosis with an enhanced safety profile in immunocompromised hosts.
Valencia-Hernandez, Ana Maria; Zhao, Guangzu; Miranda-Hernandez, Socorro; Segura-Cerda, Cristian Alfredo; Pedroza-Roldan, Cesar; Seifert, Julia; Aceves-Sanchez, Michel de Jesus; Burciaga-Flores, Mirna; Gutierrez-Ortega, Abel; Del Pozo-Ramos, Lidia; Flores-Valdez, Mario Alberto; Kupz, Andreas.
Affiliation
  • Valencia-Hernandez AM; Australian Institute of Tropical Health and Medicine, James Cook University, Cairns & Townsville, QLD, Australia.
  • Zhao G; Australian Institute of Tropical Health and Medicine, James Cook University, Cairns & Townsville, QLD, Australia.
  • Miranda-Hernandez S; Australian Institute of Tropical Health and Medicine, James Cook University, Cairns & Townsville, QLD, Australia.
  • Segura-Cerda CA; Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco (CIATEJ), A.C., Biotecnología Medica y Farmacéutica, Guadalajara, Mexico.
  • Pedroza-Roldan C; Departamento de Medicina Veterinaria, Centro Universitario de Ciencias Biologicas y Agropecuarias, Universidad de Guadalajara, Zapopan, Mexico.
  • Seifert J; Australian Institute of Tropical Health and Medicine, James Cook University, Cairns & Townsville, QLD, Australia.
  • Aceves-Sanchez MJ; Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco (CIATEJ), A.C., Biotecnología Medica y Farmacéutica, Guadalajara, Mexico.
  • Burciaga-Flores M; Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco (CIATEJ), A.C., Biotecnología Medica y Farmacéutica, Guadalajara, Mexico.
  • Gutierrez-Ortega A; Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco (CIATEJ), A.C., Biotecnología Medica y Farmacéutica, Guadalajara, Mexico.
  • Del Pozo-Ramos L; Australian Institute of Tropical Health and Medicine, James Cook University, Cairns & Townsville, QLD, Australia.
  • Flores-Valdez MA; Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco (CIATEJ), A.C., Biotecnología Medica y Farmacéutica, Guadalajara, Mexico.
  • Kupz A; Australian Institute of Tropical Health and Medicine, James Cook University, Cairns & Townsville, QLD, Australia. Electronic address: andreas.kupz@jcu.edu.au.
Vaccine ; 42(24): 126291, 2024 Sep 05.
Article in En | MEDLINE | ID: mdl-39241355
ABSTRACT
Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). While BCG protects against TB in children, its protection against pulmonary TB in adults is suboptimal, and the development of a better TB vaccine is a global health priority. Previously, we reported two recombinant BCG strains effective against murine TB with low virulence and lung pathology in immunocompromised mice and guinea pigs. We have recently combined these two recombinant BCG strains into one novel vaccine candidate (BCGΔBCG1419cESAT6-PE25SS) and evaluated its immunogenicity, efficacy and safety profile in mice. This new vaccine candidate is non-inferior to BCG in protection against TB, presents reduced pro-inflammatory immune responses and displays an enhanced safety profile.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Vaccine Year: 2024 Type: Article Affiliation country: Australia
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Vaccine Year: 2024 Type: Article Affiliation country: Australia