Evidence for the involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole by cytochrome P-450 in the covalent binding to DNA.

Mita, S; Ishii, K; Yamazoe, Y; Kamataki, T; Kato, R; Sugimura, T

Mita, S; Ishii, K; Yamazoe, Y; Kamataki, T; Kato, R; Sugimura, T.

Cancer Res ; 41(9 Pt 1): 3610-4, 1981 Sep.

Article in En | MEDLINE | ID: mdl-7020934

Subject(s)

Carbolines/metabolism; Cytochrome P-450 Enzyme System/metabolism; DNA/metabolism; Indoles/metabolism; Animals; Biotransformation; Carbolines/isolation & purification; Cocarcinogenesis; Enzyme Activation; Humans; Hydroxylation; Male; Microsomes, Liver/enzymology; Mutagens; Rats; Salmonella typhimurium/drug effects; Salmonella typhimurium/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: DNA / Carbolines / Cytochrome P-450 Enzyme System / Indoles Limits: Animals / Humans / Male Language: En Journal: Cancer Res Year: 1981 Type: Article

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