Differential incorporation of fish-oil eicosapentaenoate and docosahexaenoate into lipids of lipoprotein fractions as related to their glyceryl esterification: a short-term (postprandial) and long-term study in healthy humans.
Am J Clin Nutr
; 62(6): 1193-200, 1995 Dec.
Article
in En
| MEDLINE
| ID: mdl-7491879
ABSTRACT
We investigated how the distribution of eicosapentaenoate (EPA, 205n-3) and docosahexaenoate (DHA, 226n-3) in the sn-2 and sn-1(3) positions of fish-oil triacylglycerols influenced their respective incorporation into triacylglycerol, cholesterol esters, and phospholipids of two lipoprotein fractions low- and very-low-density lipoprotein (VL/LDL) and high-density lipoprotein (HDL). Nine healthy volunteers were studied over both a short-term (0-8 h) and a long-term (30 d) postprandial period of daily supplementation with 2 g EPA and 1.3 g DHA given as 11 g fish-oil triacylglycerol in which DHA was predominantly situated in the sn-2 position. Our results strongly suggest that the higher triacylglycerol incorporation of DHA and the higher metabolic availability of EPA compared with DHA for phospholipid accumulation (particularly in the short-term study) depend on their respective preferential sn-2/sn-1(3) positions in fish-oil triacylglycerol, emphasizing the important role of the triacylglycerol structure and its potential manipulation for modulating availability of either or both fatty acids.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Eicosapentaenoic Acid
/
Docosahexaenoic Acids
/
Lipid Metabolism
/
Glycerol
/
Lipoproteins
Limits:
Adult
/
Humans
Language:
En
Journal:
Am J Clin Nutr
Year:
1995
Type:
Article
Affiliation country:
France