Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family.

Danielsen, A G; Liu, F; Hosomi, Y; Shii, K; Roth, R A

Danielsen, A G; Liu, F; Hosomi, Y; Shii, K; Roth, R A.

Affiliation

Danielsen AG; Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305, USA.

J Biol Chem ; 270(37): 21600-5, 1995 Sep 15.

Article in En | MEDLINE | ID: mdl-7545165

Subject(s)

Insulin Resistance; Insulin-Like Growth Factor I/pharmacology; Isoenzymes/metabolism; Phosphoproteins/physiology; Protein Kinase C/metabolism; Receptor, IGF Type 1/physiology; Receptor, Insulin/physiology; Signal Transduction; Amino Acid Sequence; Animals; CHO Cells; Cattle; Cell Division; Cricetinae; Drosophila; Enzyme Activation; GTPase-Activating Proteins; Humans; Insulin Receptor Substrate Proteins; Isoenzymes/biosynthesis; Kinetics; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins/biosynthesis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Phosphotyrosine; Protein Kinase C/biosynthesis; Proteins/metabolism; Receptor, IGF Type 1/biosynthesis; Receptor, Insulin/biosynthesis; Recombinant Proteins/biosynthesis; Recombinant Proteins/metabolism; Sequence Homology, Amino Acid; Signal Transduction/drug effects; Tetradecanoylphorbol Acetate/pharmacology; Transfection; Tyrosine/analogs & derivatives; Tyrosine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Protein Kinase C / Insulin Resistance / Insulin-Like Growth Factor I / Receptor, Insulin / Signal Transduction / Receptor, IGF Type 1 / Isoenzymes Language: En Journal: J Biol Chem Year: 1995 Type: Article Affiliation country: United States

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