Occurrence of autoimmune antibodies to liver microsomal proteins associated with lethal hepatitis in LEC rats: effects of TJN-101 ((+)-(6S,7S,R-biar)- 5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooctenol) on the development of hepatitis and the autoantibodies.

Yokoi, T; Nagayama, S; Kajiwara, R; Kawaguchi, Y; Aizawa, T; Otaki, Y; Aburada, M; Kamataki, T

Yokoi, T; Nagayama, S; Kajiwara, R; Kawaguchi, Y; Aizawa, T; Otaki, Y; Aburada, M; Kamataki, T.

Affiliation

Yokoi T; Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan.

Toxicol Lett ; 76(1): 33-8, 1995 Feb.

Article in En | MEDLINE | ID: mdl-7701514

Subject(s)

Autoantibodies/biosynthesis; Autoimmune Diseases/immunology; Cyclooctanes; Dioxoles/pharmacology; Hepatitis, Animal/immunology; Lignans; Microsomes, Liver/immunology; Animals; Autoantibodies/drug effects; Autoimmune Diseases/blood; Autoimmune Diseases/mortality; Body Weight/drug effects; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis, Animal/blood; Hepatitis, Animal/mortality; Rats

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Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Autoimmune Diseases / Microsomes, Liver / Lignans / Cyclooctanes / Dioxoles / Hepatitis, Animal Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Toxicol Lett Year: 1995 Type: Article Affiliation country: Japan

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