Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

Rahman, A; Korzekwa, K R; Grogan, J; Gonzalez, F J; Harris, J W

Rahman, A; Korzekwa, K R; Grogan, J; Gonzalez, F J; Harris, J W.

Affiliation

Rahman A; Division of Biopharmaceutics, United States Food and Drug Administration, Rockville, Maryland 20857.

Cancer Res ; 54(21): 5543-6, 1994 Nov 01.

Article in En | MEDLINE | ID: mdl-7923194

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Microsomes, Liver/enzymology; Paclitaxel/metabolism; Taxoids; Biotransformation/drug effects; Humans; Hydroxylation/drug effects; Paclitaxel/analogs & derivatives; Quercetin/pharmacology; Troleandomycin/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Paclitaxel / Cytochrome P-450 Enzyme System / Taxoids Limits: Humans Language: En Journal: Cancer Res Year: 1994 Type: Article

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