Design of variants of the second domain of urinary trypsin inhibitor (R-020) with increased factor Xa inhibitory activity.

Nii, A; Morishita, H; Yamakawa, T; Matsusue, T; Hirose, J; Miura, T; Isaji, M; Horisawa, Y; Sugihara, K; Kanamori, T

Nii, A; Morishita, H; Yamakawa, T; Matsusue, T; Hirose, J; Miura, T; Isaji, M; Horisawa, Y; Sugihara, K; Kanamori, T.

Affiliation

Nii A; Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd., Tokyo.

J Biochem ; 115(6): 1107-12, 1994 Jun.

Article in En | MEDLINE | ID: mdl-7982890

Subject(s)

Factor Xa Inhibitors; Glycoproteins/chemistry; Protein Structure, Tertiary; Trypsin Inhibitors/chemistry; Amino Acid Sequence; Base Sequence; Blood Coagulation Tests; Drug Design; Factor Xa/metabolism; Glycoproteins/metabolism; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Trypsin Inhibitors/metabolism

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Glycoproteins / Trypsin Inhibitors / Protein Structure, Tertiary / Factor Xa Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biochem Year: 1994 Type: Article

Search on Google

XML

PubMed Links