CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

Morrissey, P J; Charrier, K; Braddy, S; Liggitt, D; Watson, J D

Morrissey, P J; Charrier, K; Braddy, S; Liggitt, D; Watson, J D.

Affiliation

Morrissey PJ; Department of Immunology, Immunex Research and Development Corp., Seattle, Washington 98101.

J Exp Med ; 178(1): 237-44, 1993 Jul 01.

Article in En | MEDLINE | ID: mdl-8100269

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Leukocyte Common Antigens/analysis; Weight Loss; Animals; CD4-Positive T-Lymphocytes/transplantation; Hyperplasia; Intestines/pathology; Mice; Mice, SCID

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Weight Loss / Leukocyte Common Antigens Limits: Animals Language: En Journal: J Exp Med Year: 1993 Type: Article

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