In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats.

Siegall, C B; Chace, D; Mixan, B; Garrigues, U; Wan, H; Paul, L; Wolff, E; Hellström, I; Hellström, K E

Siegall, C B; Chace, D; Mixan, B; Garrigues, U; Wan, H; Paul, L; Wolff, E; Hellström, I; Hellström, K E.

Affiliation

Siegall CB; Bristol-Myers Squibb, Pharmaceutical Research Institute, Seattle, WA 98121.

J Immunol ; 152(5): 2377-84, 1994 Mar 01.

Article in En | MEDLINE | ID: mdl-8133048

Subject(s)

ADP Ribose Transferases; Bacterial Toxins; Breast Neoplasms/therapy; Immunotoxins/therapeutic use; Virulence Factors; Animals; Antibodies, Monoclonal/metabolism; Antibodies, Monoclonal/therapeutic use; Antibodies, Monoclonal/toxicity; Antibody Affinity; Antigens, Neoplasm/metabolism; Breast Neoplasms/immunology; Breast Neoplasms/metabolism; Cytotoxicity, Immunologic; Exotoxins/pharmacokinetics; Exotoxins/therapeutic use; Exotoxins/toxicity; Female; Humans; Immunotoxins/metabolism; Immunotoxins/toxicity; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Rats; Rats, Nude; Recombinant Fusion Proteins/pharmacokinetics; Recombinant Fusion Proteins/therapeutic use; Recombinant Fusion Proteins/toxicity; Transplantation, Heterologous; Tumor Cells, Cultured/drug effects; Tumor Cells, Cultured/immunology; Tumor Cells, Cultured/metabolism; Pseudomonas aeruginosa Exotoxin A

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Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Toxins / Breast Neoplasms / Immunotoxins / ADP Ribose Transferases / Virulence Factors Limits: Animals / Female / Humans Language: En Journal: J Immunol Year: 1994 Type: Article

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