An arginine residue conserved in most G protein-coupled receptors is essential for the function of the m1 muscarinic receptor.

Zhu, S Z; Wang, S Z; Hu, J; el-Fakahany, E E

Zhu, S Z; Wang, S Z; Hu, J; el-Fakahany, E E.

Affiliation

Zhu SZ; Division of Neuroscience Research in Psychiatry, University of Minnesota Medical School, Minneapolis 55455.

Mol Pharmacol ; 45(3): 517-23, 1994 Mar.

Article in En | MEDLINE | ID: mdl-8145736

Subject(s)

Arginine/chemistry; Conserved Sequence; GTP-Binding Proteins/metabolism; Receptors, Muscarinic/metabolism; Receptors, Neurotransmitter/metabolism; Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; Ligands; Mutagenesis, Site-Directed; Rats; Receptors, Muscarinic/chemistry; Receptors, Neurotransmitter/chemistry; Signal Transduction; Tyrosine/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Receptors, Muscarinic / Conserved Sequence / Receptors, Neurotransmitter / GTP-Binding Proteins Limits: Animals Language: En Journal: Mol Pharmacol Year: 1994 Type: Article

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