Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide.

Walker, D; Flinois, J P; Monkman, S C; Beloc, C; Boddy, A V; Cholerton, S; Daly, A K; Lind, M J; Pearson, A D; Beaune, P H

Walker, D; Flinois, J P; Monkman, S C; Beloc, C; Boddy, A V; Cholerton, S; Daly, A K; Lind, M J; Pearson, A D; Beaune, P H.

Affiliation

Walker D; Department of Pharmacological Sciences, Medical School, University of Newcastle upon Tyne, U.K.

Biochem Pharmacol ; 47(7): 1157-63, 1994 Mar 29.

Article in En | MEDLINE | ID: mdl-8161344

Subject(s)

Cytochrome P-450 Enzyme System/analysis; Flavanones; Ifosfamide/metabolism; Microsomes, Liver/enzymology; Mixed Function Oxygenases/analysis; Antibodies/pharmacology; Biotransformation; Coumarins/pharmacology; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Flavonoids/pharmacology; Humans; Hydroxylation; Ifosfamide/chemistry; Inactivation, Metabolic; Microsomes, Liver/drug effects; Mixed Function Oxygenases/antagonists & inhibitors; Troleandomycin/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Cytochrome P-450 Enzyme System / Flavanones / Mixed Function Oxygenases / Ifosfamide Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Biochem Pharmacol Year: 1994 Type: Article Affiliation country: United kingdom

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