Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

Hwu, P; Shafer, G E; Treisman, J; Schindler, D G; Gross, G; Cowherd, R; Rosenberg, S A; Eshhar, Z

Hwu, P; Shafer, G E; Treisman, J; Schindler, D G; Gross, G; Cowherd, R; Rosenberg, S A; Eshhar, Z.

Affiliation

Hwu P; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

J Exp Med ; 178(1): 361-6, 1993 Jul 01.

Article in En | MEDLINE | ID: mdl-8315392

Subject(s)

Cytotoxicity, Immunologic; Immunoglobulin Variable Region/genetics; Lymphocytes, Tumor-Infiltrating/immunology; Ovarian Neoplasms/therapy; Receptors, IgG/genetics; Transfection; Cloning, Molecular; Female; Granulocyte-Macrophage Colony-Stimulating Factor/biosynthesis; Humans; Immunotherapy, Adoptive; Ovarian Neoplasms/immunology; Recombinant Fusion Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Immunoglobulin Variable Region / Transfection / Lymphocytes, Tumor-Infiltrating / Receptors, IgG / Cytotoxicity, Immunologic Limits: Female / Humans Language: En Journal: J Exp Med Year: 1993 Type: Article

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