An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.

Helminen, H J; Kiraly, K; Pelttari, A; Tammi, M I; Vandenberg, P; Pereira, R; Dhulipala, R; Khillan, J S; Ala-Kokko, L; Hume, E L

Helminen, H J; Kiraly, K; Pelttari, A; Tammi, M I; Vandenberg, P; Pereira, R; Dhulipala, R; Khillan, J S; Ala-Kokko, L; Hume, E L.

Affiliation

Helminen HJ; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

J Clin Invest ; 92(2): 582-95, 1993 Aug.

Article in En | MEDLINE | ID: mdl-8349798

Subject(s)

Cartilage/ultrastructure; Gene Deletion; Procollagen/genetics; Aging/physiology; Animals; Base Sequence; Body Weight; Bone Development; Bone and Bones/metabolism; Cartilage/growth & development; Cleft Palate/genetics; Collagen/biosynthesis; Collagen/metabolism; Cosmids; Exons; Extracellular Matrix/ultrastructure; Female; Genes, Lethal; Growth Plate/ultrastructure; Humans; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Microscopy, Electron; Molecular Sequence Data; Oligodeoxyribonucleotides; Pedigree; Polymerase Chain Reaction; Reference Values; Restriction Mapping; Sex Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cartilage / Procollagen / Gene Deletion Limits: Animals / Female / Humans / Male Language: En Journal: J Clin Invest Year: 1993 Type: Article

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