Corticotrope responsiveness to glucocorticoids is modulated via rapid CRF-mediated induction of the proto-oncogene c-fos.

Autelitano, D J; Sheppard, K E

Autelitano, D J; Sheppard, K E.

Affiliation

Autelitano DJ; Molecular Physiology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia.

Mol Cell Endocrinol ; 94(1): 111-9, 1993 Jul.

Article in En | MEDLINE | ID: mdl-8375573

Subject(s)

Corticotropin-Releasing Hormone/pharmacology; Gene Expression Regulation/drug effects; Genes, fos; Glucocorticoids/antagonists & inhibitors; Pituitary Gland, Anterior/drug effects; Pro-Opiomelanocortin/biosynthesis; Proto-Oncogene Proteins c-fos/physiology; Proto-Oncogene Proteins c-jun/physiology; beta-Endorphin/biosynthesis; Animals; Base Sequence; DNA, Antisense/pharmacology; Dexamethasone/antagonists & inhibitors; Dexamethasone/pharmacology; Drug Interactions; Feedback/drug effects; Gene Expression Regulation/genetics; Male; Molecular Sequence Data; Pituitary Neoplasms/pathology; Pro-Opiomelanocortin/genetics; Proto-Oncogene Proteins c-fos/biosynthesis; Proto-Oncogene Proteins c-fos/genetics; RNA, Heterogeneous Nuclear/genetics; Rats; Rats, Sprague-Dawley; Transcription, Genetic/drug effects; Tumor Cells, Cultured; beta-Endorphin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Pituitary Gland, Anterior / Pro-Opiomelanocortin / Corticotropin-Releasing Hormone / Beta-Endorphin / Gene Expression Regulation / Proto-Oncogene Proteins c-jun / Proto-Oncogene Proteins c-fos / Genes, fos / Glucocorticoids Limits: Animals Language: En Journal: Mol Cell Endocrinol Year: 1993 Type: Article Affiliation country: Australia

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