Localization of drug release sites from an oral sustained-release formulation of 5-ASA (Pentasa) in the gastrointestinal tract using gamma scintigraphy.
J Clin Pharmacol
; 33(8): 712-8, 1993 Aug.
Article
in En
| MEDLINE
| ID: mdl-8408731
ABSTRACT
Release of 5-ASA from a sustained release formulation (Pentasa, Ferring A/S, Copenhagen, Denmark) was monitored with plasma sampling for up to 24 hours in nine volunteers under both fasted and fed conditions. Drug absorption was correlated with location of the sustained-release microgranules in the gastrointestinal tract by gamma scintigraphy. Disintegration of the labeled tablet preparation occurred in the stomach within 20 minutes and acetylated 5-ASA was detectable in the plasma less than 60 minutes after ingestion. No significant differences were detected in either transit times through the small intestine, peak plasma acetylated 5-ASA concentration or lag time to absorption between fasted and fed individuals. Peak plasma concentration of acetylated 5-ASA usually occurred when the microgranules were present in the small intestine or ascending colon. The pharmacoscintigraphic study confirmed that 5-ASA release from the formulation occurred throughout the gastrointestinal tract, and that food effects on the in vivo behavior of the preparation were minimal.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Digestive System
/
Aminosalicylic Acids
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Clin Pharmacol
Year:
1993
Type:
Article
Affiliation country:
United kingdom