Relation of phenotype evolution of HIV-1 to envelope V2 configuration.
Science
; 260(5113): 1513-6, 1993 Jun 04.
Article
in En
| MEDLINE
| ID: mdl-8502996
ABSTRACT
Biological variability of human immunodeficiency virus type-1 (HIV-1) is involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS). Syncytium-inducing (SI) HIV-1 variants emerge in 50 percent of infected individuals during infection, preceding accelerated CD4+ T cell loss and rapid progression to AIDS. The V1 to V2 and V3 region of the viral envelope glycoprotein gp120 contained the major determinants of SI capacity. The configuration of a hypervariable locus in the V2 domain appeared to be predictive for non-SI to SI phenotype conversion. Early prediction of HIV-1 phenotype evolution may be useful for clinical monitoring and treatment of asymptomatic infection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Envelope Protein gp120
/
HIV-1
Limits:
Humans
/
Male
Language:
En
Journal:
Science
Year:
1993
Type:
Article