Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothio-phenyl)-1-inda none (L-745,337), on the cyclo-oxygenase activity of human blood prostaglandin endoperoxide synthases.

Panara, M R; Greco, A; Santini, G; Sciulli, M G; Rotondo, M T; Padovano, R; di Giamberardino, M; Cipollone, F; Cuccurullo, F; Patrono, C

Panara, M R; Greco, A; Santini, G; Sciulli, M G; Rotondo, M T; Padovano, R; di Giamberardino, M; Cipollone, F; Cuccurullo, F; Patrono, C.

Affiliation

Panara MR; Department of Pharmacology, University of Chieti G. D'Annunzio School of Medicine, Italy.

Br J Pharmacol ; 116(5): 2429-34, 1995 Nov.

Article in En | MEDLINE | ID: mdl-8581280

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Cyclooxygenase Inhibitors/pharmacology; Indans/pharmacology; Nitrobenzenes/pharmacology; Prostaglandin-Endoperoxide Synthases/blood; Sulfonamides/pharmacology; Adult; Blood Platelets/drug effects; Blood Platelets/enzymology; Blotting, Western; Dinoprostone/biosynthesis; Dinoprostone/blood; Enzyme Induction/drug effects; Female; Humans; In Vitro Techniques; Ketoprofen/pharmacology; Male; Middle Aged; Monocytes/drug effects; Monocytes/enzymology; Prostaglandin-Endoperoxide Synthases/biosynthesis; Protein Binding; Stereoisomerism; Thromboxane B2/biosynthesis; Thromboxane B2/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Anti-Inflammatory Agents, Non-Steroidal / Cyclooxygenase Inhibitors / Prostaglandin-Endoperoxide Synthases / Indans / Nitrobenzenes Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Br J Pharmacol Year: 1995 Type: Article Affiliation country: Italy

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