A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism.

Yasui, N; Otani, K; Kaneko, S; Ohkubo, T; Osanai, T; Sugawara, K; Chiba, K; Ishizaki, T

Yasui, N; Otani, K; Kaneko, S; Ohkubo, T; Osanai, T; Sugawara, K; Chiba, K; Ishizaki, T.

Affiliation

Yasui N; Department of Neuropsychiatry, Hirosaki University Hospital, Japan.

Clin Pharmacol Ther ; 59(5): 514-9, 1996 May.

Article in En | MEDLINE | ID: mdl-8646822

Subject(s)

Alprazolam/pharmacokinetics; Anti-Anxiety Agents/pharmacokinetics; Cytochrome P-450 Enzyme System/metabolism; Erythromycin/pharmacology; Mixed Function Oxygenases/metabolism; Protein Synthesis Inhibitors/pharmacology; Administration, Oral; Adult; Alprazolam/administration & dosage; Alprazolam/blood; Alprazolam/urine; Anti-Anxiety Agents/blood; Anti-Anxiety Agents/urine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Erythromycin/administration & dosage; Half-Life; Humans; Male; Protein Synthesis Inhibitors/administration & dosage; Statistics as Topic

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Collection: 01-internacional Database: MEDLINE Main subject: Anti-Anxiety Agents / Alprazolam / Protein Synthesis Inhibitors / Erythromycin / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases Type of study: Clinical_trials Limits: Adult / Humans / Male Language: En Journal: Clin Pharmacol Ther Year: 1996 Type: Article Affiliation country: Japan

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