Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

Sigalas, I; Calvert, A H; Anderson, J J; Neal, D E; Lunec, J

Sigalas, I; Calvert, A H; Anderson, J J; Neal, D E; Lunec, J.

Affiliation

Sigalas I; Cancer Research Unit, The Medical School, University of Newcastle upon Tyne, Framlington Place, UK.

Nat Med ; 2(8): 912-7, 1996 Aug.

Article in En | MEDLINE | ID: mdl-8705862

Subject(s)

Alternative Splicing; Neoplasm Proteins/genetics; Nuclear Proteins; Proto-Oncogene Proteins/genetics; Tumor Suppressor Protein p53/metabolism; 3T3 Cells; Animals; Base Sequence; Cell Transformation, Neoplastic; DNA Primers; Disease Progression; Female; Humans; Leukemia/metabolism; Mice; Molecular Sequence Data; Neoplasm Proteins/metabolism; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/pathology; Protein Binding; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-mdm2; RNA/metabolism; Transformation, Genetic; Urinary Bladder Neoplasms/metabolism; Urinary Bladder Neoplasms/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins / Alternative Splicing / Neoplasm Proteins Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 1996 Type: Article Affiliation country: United kingdom

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