TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase.

Islam, K N; Kayanoki, Y; Kaneto, H; Suzuki, K; Asahi, M; Fujii, J; Taniguchi, N

Islam, K N; Kayanoki, Y; Kaneto, H; Suzuki, K; Asahi, M; Fujii, J; Taniguchi, N.

Affiliation

Islam KN; Department of Biochemistry, Osaka University Medical School, Yamadaoka, Suita, Japan.

Free Radic Biol Med ; 22(6): 1007-17, 1997.

Article in En | MEDLINE | ID: mdl-9034240

Subject(s)

Apoptosis; Catalase/antagonists & inhibitors; Glutathione Peroxidase/antagonists & inhibitors; Reactive Oxygen Species/metabolism; Transforming Growth Factor beta/pharmacology; Adenoma, Islet Cell/metabolism; Adenoma, Islet Cell/pathology; Animals; Catalase/genetics; Cricetinae; DNA/metabolism; Flow Cytometry; Gene Expression; Glutathione Peroxidase/genetics; Hydrogen Peroxide/pharmacology; Oxidation-Reduction; Pancreatic Neoplasms/metabolism; Pancreatic Neoplasms/pathology; Peroxides/analysis; RNA, Messenger/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Catalase / Transforming Growth Factor beta / Reactive Oxygen Species / Apoptosis / Glutathione Peroxidase Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 1997 Type: Article Affiliation country: Japan

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