Characterization of a novel bisacridone and comparison with PSC 833 as a potent and poorly reversible modulator of P-glycoprotein.

Horton, J K; Thimmaiah, K N; Altenberg, G A; Castro, A F; Germain, G S; Gowda, G K; Houghton, P J

Horton, J K; Thimmaiah, K N; Altenberg, G A; Castro, A F; Germain, G S; Gowda, G K; Houghton, P J.

Affiliation

Horton JK; Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston 77555, USA. horton1@niehs.nih.gov

Mol Pharmacol ; 52(6): 948-57, 1997 Dec.

Article in En | MEDLINE | ID: mdl-9415704

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/drug effects; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Acridines/pharmacology; Cyclosporins/pharmacology; Acridones; Adenosine Triphosphatases/metabolism; Antineoplastic Agents, Phytogenic/pharmacokinetics; Antineoplastic Agents, Phytogenic/toxicity; Carcinoma, Squamous Cell/drug therapy; Carcinoma, Squamous Cell/metabolism; Drug Interactions; Drug Resistance, Multiple; Fluorescent Dyes/pharmacokinetics; Humans; KB Cells; Rhodamine 123; Rhodamines/pharmacokinetics; Tumor Cells, Cultured; Vinblastine/pharmacokinetics; Vinblastine/toxicity

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Collection: 01-internacional Database: MEDLINE Main subject: Acridines / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Cyclosporins Limits: Humans Language: En Journal: Mol Pharmacol Year: 1997 Type: Article Affiliation country: United States

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