Reduced immunoreactivity to calcium-binding proteins in Purkinje cells precedes onset of ataxia in spinocerebellar ataxia-1 transgenic mice.

Vig, P J; Subramony, S H; Burright, E N; Fratkin, J D; McDaniel, D O; Desaiah, D; Qin, Z

Vig, P J; Subramony, S H; Burright, E N; Fratkin, J D; McDaniel, D O; Desaiah, D; Qin, Z.

Affiliation

Vig PJ; Department of Neurology, University of Mississippi Medical Center, Jackson 39216, USA.

Neurology ; 50(1): 106-13, 1998 Jan.

Article in En | MEDLINE | ID: mdl-9443466

Subject(s)

Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/immunology; Purkinje Cells/chemistry; Spinocerebellar Degenerations/metabolism; Alleles; Animals; Antibodies, Monoclonal; Calbindins; Calcium-Binding Proteins/metabolism; Cerebellum/chemistry; Cerebellum/metabolism; DNA, Complementary; Disease Models, Animal; Gene Expression; Mice; Mice, Transgenic; Nerve Degeneration/metabolism; Nitric Oxide Synthase/analysis; Parvalbumins/analysis; Parvalbumins/immunology; Parvalbumins/metabolism; Purkinje Cells/enzymology; S100 Calcium Binding Protein G/analysis; S100 Calcium Binding Protein G/immunology; Spinocerebellar Degenerations/physiopathology; Transgenes

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Collection: 01-internacional Database: MEDLINE Main subject: Purkinje Cells / Calcium-Binding Proteins / Spinocerebellar Degenerations Limits: Animals Language: En Journal: Neurology Year: 1998 Type: Article Affiliation country: United States

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