Betacellulin-Pseudomonas toxin fusion proteins bind but are not cytotoxic to cells expressing HER4; correlation of EGFR for cytotoxic activity.

Mixan, B; Cohen, B D; Bacus, S S; Fell, H P; Siegall, C B

Mixan, B; Cohen, B D; Bacus, S S; Fell, H P; Siegall, C B.

Affiliation

Mixan B; Molecular Immunology Department, Bristol-Myers Squibb, Pharmaceutical Research Institute, Seattle, Washington 98121, USA.

Oncogene ; 16(9): 1209-15, 1998 Mar 05.

Article in En | MEDLINE | ID: mdl-9528863

Subject(s)

Bacterial Toxins/pharmacokinetics; Bacterial Toxins/toxicity; ErbB Receptors/physiology; Growth Substances/pharmacokinetics; Growth Substances/toxicity; Intercellular Signaling Peptides and Proteins; 3T3 Cells; Amino Acid Sequence; Animals; Bacterial Toxins/chemistry; Betacellulin; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Survival/drug effects; ErbB Receptors/biosynthesis; ErbB Receptors/drug effects; Female; Growth Substances/chemistry; Humans; KB Cells; Lymphoma, B-Cell; Mice; Molecular Sequence Data; Ovarian Neoplasms; Pseudomonas; Receptor, ErbB-4; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/pharmacokinetics; Recombinant Fusion Proteins/toxicity; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Toxins / Growth Substances / Intercellular Signaling Peptides and Proteins / ErbB Receptors Limits: Animals / Female / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 1998 Type: Article Affiliation country: United States

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