The correlation of telomerase and IL-10 with leukemia transformation in a mouse model of chronic lymphocytic leukemia (CLL).
Leuk Res
; 22(6): 509-16, 1998 Jun.
Article
in En
| MEDLINE
| ID: mdl-9678717
ABSTRACT
Telomerase activity is upregulated in activated and malignant lymphocytes. We studied the correlation of telomerase and IL-10 to leukemia transformation in the NZB mouse model of human chronic lymphocytic leukemia (CLL). Telomerase levels increased from early to late leukemic stages, likewise IL-10 gene expression levels increased with the leukemic progression. The inverse relationship of telomerase and IL-10 levels to the survival of NZB mice was also established. Our data suggested that telomerase and IL-10 were involved in transformation in the murine model of CLL and the detection of telomerase activities might be of value in the prediction of CLL progression.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Lymphocytic, Chronic, B-Cell
/
Cell Transformation, Neoplastic
/
Interleukin-10
/
Telomerase
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Leuk Res
Year:
1998
Type:
Article
Affiliation country:
United States