[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (2). 4-week repeated dose intravenous toxicity study in rats with 4-week recovery test].

Yanagi, H; Yamaguchi, K; Shimizu, K; Shichino, Y; Nishiyama, K; Mori, H; Shinomiya, K; Ueda, H; Suzuki, Y; Oida, H; Nishibata, K; Tanaka, M; Yonezawa, H; Fujita, T

Yanagi, H; Yamaguchi, K; Shimizu, K; Shichino, Y; Nishiyama, K; Mori, H; Shinomiya, K; Ueda, H; Suzuki, Y; Oida, H; Nishibata, K; Tanaka, M; Yonezawa, H; Fujita, T.

Affiliation

Yanagi H; Fukui Institute for Safety Research, ONO Pharmaceutical Co., Ltd., Japan.

J Toxicol Sci ; 23 Suppl 3: 415-34, 1998 Jul.

Article in Ja | MEDLINE | ID: mdl-9760404

Subject(s)

Glycine/analogs & derivatives; Serine Proteinase Inhibitors/toxicity; Sulfonamides/toxicity; Animals; Blood/drug effects; Body Weight/drug effects; Eating/drug effects; Eye/drug effects; Female; Glycine/administration & dosage; Glycine/toxicity; Injections, Intravenous; Kidney/drug effects; Lung/drug effects; Male; Motor Activity/drug effects; No-Observed-Adverse-Effect Level; Organ Size/drug effects; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors/administration & dosage; Sulfonamides/administration & dosage; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Serine Proteinase Inhibitors / Glycine Limits: Animals Language: Ja Journal: J Toxicol Sci Year: 1998 Type: Article Affiliation country: Japan

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