Overexpression of VEGF in testis and epididymis causes infertility in transgenic mice: evidence for nonendothelial targets for VEGF.

Korpelainen, E I; Karkkainen, M J; Tenhunen, A; Lakso, M; Rauvala, H; Vierula, M; Parvinen, M; Alitalo, K

Korpelainen, E I; Karkkainen, M J; Tenhunen, A; Lakso, M; Rauvala, H; Vierula, M; Parvinen, M; Alitalo, K.

Affiliation

Korpelainen EI; Molecular/Cancer Biology Laboratory, Haartman Institute, Helsinki, Finland.

J Cell Biol ; 143(6): 1705-12, 1998 Dec 14.

Article in En | MEDLINE | ID: mdl-9852161

Subject(s)

Endothelial Growth Factors/genetics; Epididymis/metabolism; Infertility, Male/genetics; Lymphokines/genetics; Testis/metabolism; Animals; Endothelial Growth Factors/biosynthesis; Endothelium, Vascular/metabolism; Endothelium, Vascular/pathology; Epididymis/blood supply; Epididymis/pathology; Gene Expression Regulation; Genetic Vectors; Humans; Hyperplasia; Infertility, Male/metabolism; Infertility, Male/pathology; Lymphokines/biosynthesis; Male; Mammary Tumor Virus, Mouse/genetics; Mice; Mice, Transgenic; Proto-Oncogene Proteins/genetics; Receptor Protein-Tyrosine Kinases/genetics; Receptors, Growth Factor/genetics; Receptors, Mitogen/genetics; Receptors, Vascular Endothelial Growth Factor; Seminiferous Tubules/pathology; Spermatogenesis; Terminal Repeat Sequences; Testis/blood supply; Testis/pathology; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Testis / Endothelial Growth Factors / Lymphokines / Epididymis / Infertility, Male Type of study: Etiology_studies Limits: Animals / Humans / Male Language: En Journal: J Cell Biol Year: 1998 Type: Article Affiliation country: Finland

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