Action of selective serotonin reuptake inhibitor on aggressive behavior in adult rat submitted to the neonatal malnutrition
Arq. neuropsiquiatr
; Arq. neuropsiquiatr;59(3A): 499-503, Sept. 2001. graf, tab
Article
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| ID: lil-295899
Biblioteca responsable:
BR1.1
ABSTRACT
The effect of the malnutrition during suckling on the aggressiveness was investigated in adult rats treated or not with citalopram, a selective serotonin reuptake inhibitor (SSRI). The animals were divided into two groups according to the diet used nourished groupó the rats received the control diet with 23 per cent protein during the life; and malnourished groupó the rats had its mothers submitted to diet with 7.8 per cent protein during suckling. At 120 days of age, each group was sub-divided according to the treatment acute ó consisting a single i.p. injection of saline solution or 20-mg/Kg citalopram; chronic ó consisting the single injections (1 per day during 14 days) of saline or 20 mg/Kg citalopram. The acute or chronic treatment with SSRI reduces aggressive response in nourished rats, but not in malnourished ones. Thus, the malnutrition during the critical period of brain development seems to induce durable alterations in the function of the serotoninergic neurotransmission
Texto completo:
1
Colección:
01-internacional
Banco de datos:
LILACS
Asunto principal:
Conducta Animal
/
Citalopram
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Inhibidores Selectivos de la Recaptación de Serotonina
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Agresión
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Trastornos Nutricionales
Límite:
Animals
Idioma:
En
Revista:
Arq Neuropsiquiatr
/
Arq. neuropsiquiatr
/
Arq. neuropsiquiatr. (Online)
/
Arquivos de neuro-psiquiatria (Impresso)
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Brasil