The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells.
Oncogene
; 18(4): 905-15, 1999 Jan 28.
Article
en En
| MEDLINE
| ID: mdl-10023666
ABSTRACT
The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alphaE-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alphaE-catenin allele. The alphaE-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genes Supresores de Tumor
/
Neoplasias del Colon
/
Proteínas del Citoesqueleto
/
Proteínas de Unión al ADN
/
Invasividad Neoplásica
Límite:
Humans
Idioma:
En
Revista:
Oncogene
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
1999
Tipo del documento:
Article
País de afiliación:
Bélgica