The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor.
Mol Cell Biol
; 19(4): 2594-600, 1999 Apr.
Article
en En
| MEDLINE
| ID: mdl-10082525
ABSTRACT
The p53 tumor suppressor gene is mutated in over 50% of human cancers, resulting in inactivation of the wild-type (wt) p53 protein. The most notable biochemical feature of p53 is its ability to act as a sequence-specific transcriptional activator. Through use of the suppression subtractive hybridization differential screening technique, we identified c-fos as a target for transcriptional stimulation by p53 in cells undergoing p53-mediated apoptosis. Overexpression of wt p53 induces c-fos mRNA and protein. Moreover, in vivo induction of c-fos in the thymus following whole-body exposure to ionizing radiation is p53 dependent. p53 responsiveness does not reside in the basal c-fos promoter. Rather, a distinct region within the c-fos gene first intron binds specifically to p53 and confers upon the c-fos promoter the ability to become transcriptionally activated by wt p53. Identification of c-fos as a specific target for transcriptional activation by p53 establishes a direct link between these two pivotal regulatory proteins and raises the possibility that c-fos contributes to some of the biological effects of p53.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Activación Transcripcional
/
Proteína p53 Supresora de Tumor
/
Proteínas Proto-Oncogénicas c-fos
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Israel